CRISPR in basic research

CRISPR genome editing technology has allowed scientists to perform a number of complex experiments with speed and accuracy more than ever before. Genetic screening provides a powerful approach for identifying genes, pathways and mechanisms involved in a given phenotype or biological processes.

Manipulating cell lines and creating cell and animal models, which researchers can use to accelerate research, has been a fundamental contribution of CRISPR technology. High fidelity multi guide libraries are now routinely offered as products for conducting genetic knockout screens. Utilizing the core CRISPR technology, genes of interest can now be activated, silenced and manipulated to understand their contributions.

These are all seemingly disconnected problems. But solving these problems may have something common at the core: Effective and intelligent use of gene-editing.

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